Naegeli-Franceschetti-Jadassohn syndrome

Naegeli-Franceschetti-Jadassohn syndrome is a rare ectodermal dysplasia that affects the skin, Sweat glands, nails, and teeth. The cardinal features are absence of dermatoglyphics (fingerprints), reticular cutaneous hyperpigmentation (starting at about the age of 2 years without a preceding Inflammatory stage), hypohidrosis with diminished Sweat gland Function and discomfort provoked by heat, Nail dystrophy, Tooth enamel defects, and moderate hyperkeratosis of the palms and soles.

Organ Affected

  • Skin System (Integumentary System)
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